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Genetic instability in cancer / guest editor, T. Lindahl - vi, 353 pages : illustrations ; 26 cm - Cancer surveys, v. 28 0261-2429 ; . - Cancer surveys ; volume 28. .

"Published for the Imperial Cancer Research Fund."

Includes bibliographical references and index

Introduction -- DNA synthesis errors, mutators and cancer -- DNA polymerase and the control of DNA damage induced mutagenesis in eukaryotes -- Patterns of mutation in cancer cells -- Mismatch repair and cancer -- Genomic instability and tolerance to alkylating agents -- The relationship of DNA methylation to cancer -- Neoplastic transformation: the contrasting stability of human and mouse cells -- Damage inducible mutagenesis: recent insights into the activities of the Umu family of mutagenesis proteins -- The relevance of bacterial mutators to understanding human cancer -- Mutation in resting cells: the role of endogenous DNA damage -- TP53 tumour suppressor gene: clues to molecular carcinogenesi and cancer therapy -- Telomere maintenance in tumour cells -- Regulation of genomic instability in preneoplastic cells -- Chromosome abnormalities in leukemia: the 11q23 paradigm -- Clonal chromosome abnormalities in neoplastic cells: evidence of genetic instability? -- DNA damage detection by DNA dependent protein kinase and related enzymes -- Mammalian X ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation -- Mechanism of V(D)J recombination -- Transrearrangements as biomarkers for risk of lymphoid malignancy -- Many mutations in cancers

ISBN: 0879694858

LCCN: 97116881

Subjects--Topical Terms:
Cancer--Genetic aspects
DNA repair
Chromosome abnormalities
Neoplasms--genetics
DNA repair
Chromosome Aberrations

LC Class. No.: RC268.4 / .G4465 1996

Dewey Class. No.:

National Library of Medicine Call No.: QZ202 / .G32 1996