Advances in clinical chemistry / edited by Gregory S. Makowski.

Contents -- Contributors -- Preface -- Chapter 1: Tumor Markers in Detection of Lung Cancer -- 1. Abstract -- 2. Introduction -- 3. Blood/Serum Tumor Markers in the Detection of Lung Cancers -- 4. Role of Serum Tumor Markers in the Detection of Lung Cancers -- 5. Role of Other Serum Markers in the Detection of Lung Cancers -- 6. Role of a Tumor Marker Panel in Improving the Detection of Lung Cancers -- 7. Value of Less Frequently Used Markers in the Diagnosis of Lung Cancers -- 8. Summary and Conclusions -- References -- Chapter 2: Advances in Serum Protein Electrophoresis -- 1. Abstract -- 2. Introduction -- 3. Technique -- 4. Instruments -- 5. Precision -- 6. Comparison with Gel-Based Techniques -- 7. Reference Intervals -- 8. Electrophoretic Patterns -- 9. Online Processing of Digital Absorbance Data -- 10. Detection of Monoclonal Proteins -- 11. Typing of Monoclonal Proteins -- 12. Urine and Body Fluid Analysis -- 13. Quality Control -- 14. Interferences -- 15. "Open" Capillary Electrophoresis Systems -- 16. Conclusions -- Acknowledgment -- References -- Chapter 3: Aspirin Resistance: A. Review Of Diagnostic. Methodology, Mechanisms, and Clinical Utility -- 1. Abstract -- 2. Introduction -- 3. Aspirin: Mechanism of Action -- 4. Methods to Detect Aspirin Resistance -- 5. Aspirin Resistance Associated with Adverse Outcomes -- 6. Mechanisms of Aspirin Resistance -- 7. Aspirin Resistance Associated with Cardiovascular and Cerebrovascular Disease -- 8. Summary and Recommendations -- References -- Chapter 4: Vitreous Fluid Biomarkers -- 1. Abstract -- 2. Introduction -- 3. Methods -- 4. Molecular Biology -- 5. Ocular Disease and Clinical Significance -- 6. Conclusions -- References -- Chapter 5: Tumor-associated Carbonic Anhydrases and Their Clinical Significance -- 1. Abstract -- 2. Carbonic Anhydrases -- 3. Basic Characteristics of CA IX and CA XII -- 4. Regulation of CA IX/CA XII Expression -- 5. Distribution of CA IX/CA XII in Tumors and Their Clinical Usefulness -- 6. Role of CA IX/CA XII in Tumor Progression -- 7. CA IX and CA XII as Molecular Targets for Anticancer Therapy -- 8. Concluding Remarks -- Acknowledgments -- References -- Chapter 6: Mitochondrial Disease: Maintenance of Mitochondrial Genome and Molecular Diagnostics -- 1. Abstract -- 2. Introduction -- 3. Human Mitochondrial DNA -- 4. Maintenance of Mitochondrial DNA -- 5. Pathogenesis of Mitochondrial DNA Mutation -- 6. Tests of Mitochondrial DNA -- 7. Mitochondrial DNA in Common Disease -- 8. Nuclear DNA Mutations and Mitochondrial Disease -- 9. Perspectives -- 10. Conclusion and Remarks -- Acknowledgments -- References -- Chapter 7: Microfluidic Enzyme-Linked Immunosorbent Assay Technology -- 1. Abstract -- 2. Introduction -- 3. Key Issues in Develo.