The paraoxonases : their role in disease development and xenobiotic metabolism / editors, B. Mackness [and others]

Selected conference papers

Contributors Preface PART 1 The Bert La Du Memorial Lecture Paraoxonases: An Historical Perspective C.E. Furlong PART 2 PONs and Atherosclerosis 1. Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form Mira Rosenblat, Orly Sapir and Michael Aviram 2. Paraoxonase-1 and Cardiovascular Disease B. Mackness and M.I. Mackness 3. Oxidative Stress and Antioxidants and PON 1 in Health and Disease Eser Yildirim Sozmen, Ferhan Girgin Sagin, Meral Kayikcioglu and Bulent Sozmen 4. D-4F Increases Paraoxonase 1 Activity in HDL Greg Hough 5. Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids H. Jakubowski 6. The Role of PON2 and PON3 in Atherosclerosis and Related Traits N. Bourquard, D.M. Shih, C.J. Ng, N. Villa-Garcia, K. Nakamura, D.A. Stoltz, E. Ozer, V. Grijalva, N. Rozengurt, S. Y. Hama, J. Zabner, M. Navab, A.M. Fogelman and S.T. Reddy 7. Paraoxonase 1 and Postprandial Lipemia A. Alipour, B. Coll, A.P. Rietveld, Marsillach, J. Camps, J. Joven, J.W.F. Elte and M. Castro Cabezas 8. PON1 Genotypes and Coronary Heart Disease M. Roest and H.A.M. Voorbij PART 3 PON1 Structure 9. Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents David T. Yeung, David E. Lenz and Douglas M. Cerasoli 10. Stabilisation of Active Form of Natural Human PON1 Requires HPBP D. Rochu, E. Chabriere, M. Elias, F. Renault, C. Clery-Barraud and P. Masson PART 4 PONs in Disease other than Atherosclerosis 11. Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection J. Marsillach, S. Parra, N. Ferre, B. Coll, C. Alonso-Villaverde, J. Joven and J. Camps 12. Age-Related Alterations in PON1 I. Seres, T. Fulop, G. Paragh and A. Khalil PART 5 PON and Toxicology 13. Paraoxonase (PON1) and Organophosphate Toxicity L.G. Costa, T.B. Cole, K.L. Jansen and C.E. Furlong 14. Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides A.F. Hernández, O. López, G. Pena, J.L. Serrano, T. Parrón, L. Rodrigo, F. Gil and A. Pla PART 6 PON-Genetics and Regulation 15. Transcriptional Regulation of the Paraoxonase Genes S. P. Deakin and R. W. James 16. Effect of Lipid Lowering Medications on PON 1 G. Paragh, M. Harangi and L Seres 17. The Functional Consequences of Polymorphisms in the Human PON1 Gene C.E. Furlong, R.J Richter, W.-F. Li, V.H. Brophy, C. Carlson, M. Rieder, D. Nickerson, L.G. Costa, J. Ranchalis, A.J. Lusis, D.M. Shih, A. Tward and G.P. Jarvik 18. Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans C. Dalgård PART 7 PONs Biochemistry 19. PONs' Natural Substrates – The Key for their Physiological Roles D.I. Draganov and J.F. Teiber 20. Paraoxonases, Quorum Sensing, and Pseudomonas aeruginosa D.A. Stoltz, E.A. Ozer and J. Zabner Index

Features a distillation of the plenary lectures presented at the International Conference on Paraoxonases, held in Hajduszoboszlo, Hungary, in September 2006. This book offers a review of paraoxonase research