TY - BOOK AU - Sarker,Satyajit D AU - Nahar,Lutfun TI - Chemistry for pharmacy students: general, organic and natural product chemistry SN - 9780470017807 AV - QD31.3 .S377 2007 PY - 2007///] CY - Chichester, England, Hoboken, NJ PB - John Wiley and Sons KW - Chemistry KW - Textbooks N1 - Includes bibliographical references and index; Contents; Preface; 1 Introduction; 1.1 Role of chemistry in modern life; 1.2 Physical properties of drug molecules; 2 Atomic structure and bonding; 2.1 Atoms, elements and compounds; 2.2 Atomic structure: orbitals and electronic configurations; 2.3 Chemical bonding theories: formation of chemical bonds; 2.4 Electronegativity and chemical bonding; 2.5 Bond polarity and intermolecular forces; 2.6 Significance of chemical bonding in drug?receptor interactions; 3 Stereochemistry; 3.1 Stereochemistry: definition; 3.2 Isomerism; 3.3 Significance of stereoisomerism in determining drug action and toxicity; 3.4 Synthesis of chiral molecules; 3.5 Separation of stereoisomers: resolution of racemic mixtures; 3.6 Compounds with stereocentres other than carbon; 3.7 Chiral compounds that do not have a tetrahedral atom with four different groups; 4 Organic functional groups; 4.1 Organic functional groups: definition and structural features; 4.2 Hydrocarbons; 4.3 Alkanes, cycloalkanes and their derivatives; 4.4 Alkenes and their derivatives; 4.5 Alkynes and their derivatives; 4.6 Aromatic compounds and their derivatives; 4.7 Heterocyclic compounds and their derivatives; 4.8 Nucleic acids; 4.9 Amino acids and peptides; 4.10 Importance of functional groups in determining drug actions and toxicity; 4.11 Importance of functional groups in determining stability of drugs; 5 Organic reactions; 5.1 Types of organic reaction; 5.2 Radical reactions: free radical chain reactions; 5.3 Addition reactions; 5.4 Elimination reactions: 1,2-elimination or ?-elimination; 5.5 Substitution reactions; 5.6 Hydrolysis; 5.7 Oxidation?reduction reactions; 5.8 Pericyclic reactions; 6 Natural product chemistry; 6.1 Introduction to natural products drug discovery process; 6.2 Alkaloids; 6.3 Carbohydrates; 6.4 Glycosides; 6.5 Terpenoids; 6.6 Steroids; 6.7 Phenolics ER -