TY  - BOOK
AU  - Duffus,John H.
ED  - International Seminar on Assessment of Carcinogenic Risk from Occupational Exposure to Inorganic Substances
ED  - Royal Society of Chemistry (Great Britain)
TI  - Carcinogenicity of inorganic substances: risks from occupational exposure 
SN  - 0854044299
AV  - QZ202 .S941 1997
PY  - 1997///]
CY  - Cambridge
PB  - Royal Society of Chemistry
KW  - Carcinogens
KW  - Congresses
KW  - Cancer
KW  - Etiology Congresses
KW  - Industrial toxicology
KW  - Neoplasms
KW  - etiology congresses
KW  - Occupational Exposure
KW  - congresses
N1  - Front Cover; Carcinogenicity of Inorganic Substances: Risks from Occupational Exposure; Copyright Page; Table of Contents; Preface; Organizers, Sponsors, Members of the Scientific and Editorial Board and Steering Organizing Committee; Setting the Scene: The Scientific Context; Part 1: Scientific Presentations; Chapter 1. General Overview of the Scientific Presentations; 1 Bio-inorganic Chemistry; 2 Physico-chemical Characterisation of Exposures; 3 Experimental Studies; 4 Epidemiological Studies; Chapter 2. Bio-inorganic Chemistry and Cancer; 1 The Essential Elements; 2 Attack on DNA; 3 Buffering and Homeostasis of Ions; 4 Conclusion; References; Chapter 3. Physico-chemical Properties of Inorganic Particles Controlling Biological Activity; 1 Introduction; 2 Quantitative Description of Particle Morphology; 3 Carcinogenicity of Fibrous Particles; 4 Conclusions; References; Chapter 4. Mineralogical Factors and the Relationship of Fibres and Dusts in Humans to Disease; 1 Introduction; 2 Particles in the General Population; 3 Fibre Burden and Disease Caused by Asbestos; References; Chapter 5. In Vitro Studies of Genotoxicity and their Significance; 1 Introduction; 2 Genotoxicity Studies; 3 Cytotoxicity, Cell Viability; 4 Present and Further Research Areas; 5 Conclusions; References; Chapter 6. Sequence of Events in Lung Carcinogenesis; 1 Interindividual Variation in Cancer Susceptibility; 2 Field Cancerization Theory; 3 Somatic Genetic Changes Commonly Detected in Lung Cancer; 4 Putative Role For Autocrine Loops in the Development of Lung Cancer; 5 Sequence of Events in Lung Carcinogenesis; References; Chapter 7. The Significance of Toxicokinetics of Solid Particles in the Rat Lung; 1 Introduction; 2 Design of Retention Measurements; 3 Generic Response in Particle Inhalation Studies; 4 Dust Overload in Lungs; 5 Irreversibility of Clearance Retardation; 6 Migration of Particles to Lung-associated Lymph Nodes; 7 Model Calculation of Retention Kinetics of Solid Particles; 8 The Concept of Maximum Tolerated Dose (MTD) in Chronic Inhalation Studies; 9 Fibres; 10 Quartz; 11 Solid Ultrafine Particles; References; Chapter 8. Mechanisms and Significance of Particle Overload; 1 Background; 2 A Definition of Dust Overloading; 3 Overload Studies; 4 Particle Clearance Kinetics; 5 Mechanistic Concepts; 6 The Reversibility of Overload; 7 Overload in Other Species; 8 Does Dust Overload Pertain to Humans?; 9 The Implications of Overload; 10 Relatable Issues; 11 Conclusions; 12 Acknowledgement; References""
ER  -