TY  - BOOK
AU  - Lindahl,T.
ED  - Imperial Cancer Research Fund (Great Britain)
TI  - Genetic instability in cancer
T2  - Cancer surveys,
SN  - 0879694858
AV  - RC268.4 .G4465 1996
PY  - 1996///
CY  - Plainview, NY
PB  - Cold Spring Harbor Laboratory Press
KW  - Cancer
KW  - Genetic aspects
KW  - DNA repair
KW  - Chromosome abnormalities
KW  - Neoplasms
KW  - genetics
KW  - Chromosome Aberrations
N1  - "Published for the Imperial Cancer Research Fund."; Includes bibliographical references and index; Introduction; -- DNA synthesis errors, mutators and cancer; -- DNA polymerase and the control of DNA damage induced mutagenesis in eukaryotes; -- Patterns of mutation in cancer cells; -- Mismatch repair and cancer; -- Genomic instability and tolerance to alkylating agents; -- The relationship of DNA methylation to cancer; -- Neoplastic transformation: the contrasting stability of human and mouse cells; -- Damage inducible mutagenesis: recent insights into the activities of the Umu family of mutagenesis proteins; -- The relevance of bacterial mutators to understanding human cancer; -- Mutation in resting cells: the role of endogenous DNA damage; -- TP53 tumour suppressor gene: clues to molecular carcinogenesi and cancer therapy; -- Telomere maintenance in tumour cells; -- Regulation of genomic instability in preneoplastic cells; -- Chromosome abnormalities in leukemia: the 11q23 paradigm; -- Clonal chromosome abnormalities in neoplastic cells: evidence of genetic instability?; -- DNA damage detection by DNA dependent protein kinase and related enzymes; -- Mammalian X ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation; -- Mechanism of V(D)J recombination; -- Transrearrangements as biomarkers for risk of lymphoid malignancy; -- Many mutations in cancers
ER  -