Carcinogenicity of inorganic substances : risks from occupational exposure / chief editor, J.H. Duffus.

Front Cover Carcinogenicity of Inorganic Substances: Risks from Occupational Exposure Copyright Page Table of Contents Preface Organizers, Sponsors, Members of the Scientific and Editorial Board and Steering Organizing Committee Setting the Scene: The Scientific Context Part 1: Scientific Presentations Chapter 1. General Overview of the Scientific Presentations 1 Bio-inorganic Chemistry 2 Physico-chemical Characterisation of Exposures 3 Experimental Studies 4 Epidemiological Studies Chapter 2. Bio-inorganic Chemistry and Cancer 1 The Essential Elements 2 Attack on DNA 3 Buffering and Homeostasis of Ions 4 Conclusion References Chapter 3. Physico-chemical Properties of Inorganic Particles Controlling Biological Activity 1 Introduction 2 Quantitative Description of Particle Morphology 3 Carcinogenicity of Fibrous Particles 4 Conclusions References Chapter 4. Mineralogical Factors and the Relationship of Fibres and Dusts in Humans to Disease 1 Introduction 2 Particles in the General Population 3 Fibre Burden and Disease Caused by Asbestos References Chapter 5. In Vitro Studies of Genotoxicity and their Significance 1 Introduction 2 Genotoxicity Studies 3 Cytotoxicity, Cell Viability 4 Present and Further Research Areas 5 Conclusions References Chapter 6. Sequence of Events in Lung Carcinogenesis 1 Interindividual Variation in Cancer Susceptibility 2 Field Cancerization Theory 3 Somatic Genetic Changes Commonly Detected in Lung Cancer 4 Putative Role For Autocrine Loops in the Development of Lung Cancer 5 Sequence of Events in Lung Carcinogenesis References Chapter 7. The Significance of Toxicokinetics of Solid Particles in the Rat Lung 1 Introduction 2 Design of Retention Measurements 3 Generic Response in Particle Inhalation Studies 4 Dust Overload in Lungs 5 Irreversibility of Clearance Retardation 6 Migration of Particles to Lung-associated Lymph Nodes 7 Model Calculation of Retention Kinetics of Solid Particles 8 The Concept of Maximum Tolerated Dose (MTD) in Chronic Inhalation Studies 9 Fibres 10 Quartz 11 Solid Ultrafine Particles References Chapter 8. Mechanisms and Significance of Particle Overload 1 Background 2 A Definition of Dust Overloading 3 Overload Studies 4 Particle Clearance Kinetics 5 Mechanistic Concepts 6 The Reversibility of Overload 7 Overload in Other Species 8 Does Dust Overload Pertain to Humans? 9 The Implications of Overload 10 Relatable Issues 11 Conclusions 12 Acknowledgement References""