000			03802 am a2200337 i 4500
008			980831s1997 enk# 001 0#eng d
020			_a0854044299
035			_a(OCoLC)
040			_aBAUN _beng _cBAUN _erda
049			_aBAUN_MERKEZ
050	0	4	_aQZ202 _b.S941 1997
111	2		_aInternational Seminar on Assessment of Carcinogenic Risk from Occupational Exposure to Inorganic Substances _d(1995 : _cLuxembourg) _9103947
245	1	0	_aCarcinogenicity of inorganic substances : _brisks from occupational exposure / _cchief editor, J.H. Duffus.
264		1	_aCambridge : _bRoyal Society of Chemistry, _c[1997]
264		4	_c©1997
300			_aix, 286 pages ; _c24 cm.
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
505		0	_tFront Cover _tCarcinogenicity of Inorganic Substances: Risks from Occupational Exposure _tCopyright Page _tTable of Contents _tPreface _tOrganizers, Sponsors, Members of the Scientific and Editorial Board and Steering Organizing Committee _tSetting the Scene: The Scientific Context _tPart 1: Scientific Presentations _tChapter 1. General Overview of the Scientific Presentations _t1 Bio-inorganic Chemistry _t2 Physico-chemical Characterisation of Exposures _t3 Experimental Studies _t4 Epidemiological Studies _tChapter 2. Bio-inorganic Chemistry and Cancer _t1 The Essential Elements _t2 Attack on DNA _t3 Buffering and Homeostasis of Ions _t4 Conclusion _tReferences _tChapter 3. Physico-chemical Properties of Inorganic Particles Controlling Biological Activity _t1 Introduction _t2 Quantitative Description of Particle Morphology _t3 Carcinogenicity of Fibrous Particles _t4 Conclusions _tReferences _tChapter 4. Mineralogical Factors and the Relationship of Fibres and Dusts in Humans to Disease _t1 Introduction _t2 Particles in the General Population _t3 Fibre Burden and Disease Caused by Asbestos _tReferences _tChapter 5. In Vitro Studies of Genotoxicity and their Significance _t1 Introduction _t2 Genotoxicity Studies _t3 Cytotoxicity, Cell Viability _t4 Present and Further Research Areas _t5 Conclusions _tReferences _tChapter 6. Sequence of Events in Lung Carcinogenesis _t1 Interindividual Variation in Cancer Susceptibility _t2 Field Cancerization Theory _t3 Somatic Genetic Changes Commonly Detected in Lung Cancer _t4 Putative Role For Autocrine Loops in the Development of Lung Cancer _t5 Sequence of Events in Lung Carcinogenesis _tReferences _tChapter 7. The Significance of Toxicokinetics of Solid Particles in the Rat Lung _t1 Introduction _t2 Design of Retention Measurements _t3 Generic Response in Particle Inhalation Studies _t4 Dust Overload in Lungs _t5 Irreversibility of Clearance Retardation _t6 Migration of Particles to Lung-associated Lymph Nodes _t7 Model Calculation of Retention Kinetics of Solid Particles _t8 The Concept of Maximum Tolerated Dose (MTD) in Chronic Inhalation Studies _t9 Fibres _t10 Quartz _t11 Solid Ultrafine Particles _tReferences _tChapter 8. Mechanisms and Significance of Particle Overload _t1 Background _t2 A Definition of Dust Overloading _t3 Overload Studies _t4 Particle Clearance Kinetics _t5 Mechanistic Concepts _t6 The Reversibility of Overload _t7 Overload in Other Species _t8 Does Dust Overload Pertain to Humans? _t9 The Implications of Overload _t10 Relatable Issues _t11 Conclusions _t12 Acknowledgement _tReferences""
650		0	_aCarcinogens _vCongresses. _9103948
650		0	_aCancer _xEtiology Congresses. _9103949
650		0	_aIndustrial toxicology _vCongresses. _9103950
650		0	_aCarcinogens _vCongresses. _9103948
650		2	_aNeoplasms _xetiology congresses. _9103951
650		0	_aOccupational Exposure _xcongresses. _9103952
700	1		_aDuffus, John H. _986618 _eedt
710	2		_943135 _aRoyal Society of Chemistry (Great Britain)
900			_a3770
942			_2lcc _cKT
999			_c3574 _d3574